441 drivers have competed in at least one NASCAR Sprint Cup Series race at Talladega; 306 in more than one.
- Dave Marcis and Terry Labonte lead the series in starts at Talladega with 61 each. Tony Stewart leads all active drivers with 33 starts; followed by Dale Earnhardt Jr. with 32.
- Jimmie Johnson leads all active drivers in the NASCAR Sprint Cup Series in average starting position at Talladega with a 9.750.
- A total of 68 drivers have made their first series start at Talladega; Jamie McMurray (10/06/2002) is the only active driver to make his series debut at Talladega Superspeedway.
- 45 different drivers have won at Talladega Superspeedway, led by Dale Earnhardt with 10. Dale Earnhardt Jr. leads all active drivers with six.
- 2012 series champion Brad Keselowski (04/26/2009) and Brian Vickers (10/08/2006) posted their first NASCAR Sprint Cup Series wins at Talladega.
- Nine drivers in the NASCAR Sprint Cup Series have posted consecutive wins at Talladega; Dale Earnhardt Jr. leads the series in consecutive wins at Talladega after posting four-straight from the fall of 2001 – 2003.
- Brad Keselowski is the only active series driver to win at Talladega in his first appearance.
- Matt Kenseth competed at Talladega Superspeedway 25 times before winning the fall of 2012; the longest span of any the 11 active NASCAR Sprint Cup Series winners.
- Matt Kenseth (25), Tony Stewart (19), Kevin Harvick (18), and David Ragan (12) all made 10 or more attempts before their first win at Talladega.
- Kurt Busch leads the series among active drivers with the most NASCAR Sprint Cup Series starts at Talladega without visiting Victory Lane at 30; followed by Ryan Newman with 28.
- Buddy Baker and Tony Stewart are tied for the series' most runner-up finishes at Talladega with six each.
- NASCAR Hall of Famer Dale Earnhardt leads the series in top-five finishes at Talladega with 23. Dale Earnhardt Jr. leads all active drivers with 12.
- Dale Earnhardt leads the series in top-10 finishes at Talladega with 27. Dale Earnhardt Jr. leads all active drivers with 16.
- Ricky Stenhouse Jr. leads all active drivers in the NASCAR Sprint Cup Series in average finishing position at Talladega with a 12.200.
- Dale Earnhardt Jr. leads all active drivers in the NASCAR Sprint Cup Series in laps led at Talladega with 960 laps led in 32 starts.
- Three female drivers have competed at Talladega in the NASCAR Sprint Cup Series: Janet Guthrie, Patty Moise and Danica Patrick.